Phosphoinositide 3-kinase in Health and Disease, Volume 1
Christian Rommel, Bart Vanhaesebroeck, Peter K. Vogt- PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone
- The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being closely monitored; however, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target
- From humble beginnings over 25 years ago as a lipid kinase activity associated with certain oncoproteins, PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis, with the first clinical trials of PI3K pathway inhibitors now in progress. Here the authors give a brief overview of some key discoveries in the PI3K area and their impact, and include thoughts on the current state of the field, and where it could go from here.
권:
1
년:
2010
판:
1st
출판사:
Springer
언어:
english
페이지:
318
ISBN 10:
364213663X
ISBN 13:
9783642136634
시리즈:
Current Topics in Microbiology and Immunology
파일:
PDF, 4.47 MB
IPFS:
,
english, 2010
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